Multixenobiotic resistance, acetyl-choline esterase activity and total oxyradical scavenging capacity of the Arctic spider crab, Hyasaraneus, following exposure to bisphenol A, tetra bromo diphenyl ether and diallyl phthalate.
Identifieur interne : 000D49 ( Main/Exploration ); précédent : 000D48; suivant : 000D50Multixenobiotic resistance, acetyl-choline esterase activity and total oxyradical scavenging capacity of the Arctic spider crab, Hyasaraneus, following exposure to bisphenol A, tetra bromo diphenyl ether and diallyl phthalate.
Auteurs : Christophe Minier [France] ; Joëlle Forget-Leray ; Anne Bj Rnstad ; Lionel CamusSource :
- Marine pollution bulletin [ 0025-326X ] ; 2008.
English descriptors
- KwdEn :
- Acetylcholinesterase (metabolism), Animals, Arctic Regions, Benzhydryl Compounds, Brachyura (drug effects), Brachyura (enzymology), Digestive System (drug effects), Drug Resistance, Multiple, Gene Expression Regulation (drug effects), Halogenated Diphenyl Ethers, Hydrocarbons, Brominated (pharmacology), Hydrocarbons, Brominated (toxicity), Muscles (drug effects), Muscles (enzymology), Phenols (pharmacology), Phenols (toxicity), Phenyl Ethers (pharmacology), Phenyl Ethers (toxicity), Phthalic Acids (toxicity), Polybrominated Biphenyls, Reactive Oxygen Species (metabolism), Water Pollutants (pharmacology), Water Pollutants (toxicity), Xenobiotics (pharmacology), Xenobiotics (toxicity).
- MESH :
- chemical , metabolism : Acetylcholinesterase, Reactive Oxygen Species.
- chemical , pharmacology : Hydrocarbons, Brominated, Phenols, Phenyl Ethers, Water Pollutants, Xenobiotics.
- chemical , toxicity : Hydrocarbons, Brominated, Phenols, Phenyl Ethers, Phthalic Acids, Water Pollutants, Xenobiotics.
- geographic : Arctic Regions, Benzhydryl Compounds, Halogenated Diphenyl Ethers, Polybrominated Biphenyls.
- drug effects : Brachyura, Digestive System, Gene Expression Regulation, Muscles.
- enzymology : Brachyura, Muscles.
- Animals, Drug Resistance, Multiple.
Abstract
The Arctic has become a sink for persistent organic pollutants (POPs) originating from lower latitudes, and relatively high levels have been found in different biota. Recent studies have identified detrimental effects on wildlife including endocrine disruption, impairment of enzyme activity, and reduced immune function. The Arctic spider crab, Hyas araneus, shown interesting potential for its use as sentinel organism in polar ecosystems. This study investigated the effect of 2,2',4,4'-tetra bromo diphenyl ether (BPDE), bisphenol A (BPA), and diallyl phthalte (DPA) on H. araneus in a three weeks exposure study. Expression of multixenibiotic resistance (MXR) proteins has been studied using the C219 monoclonal antibody which allows identifying an immunoreactive protein of 40 kDa in the digestive gland while no such protein could be observed in the gills. Expression of this protein was increased by exposure to DPA (+75%; p<0.05, n=10). All compounds significantly affected muscle acetylcholine esterase (AChE) activity (p<0.05, n=10) with 50 microg/L DPA having the strongest effect by lowering the value to 37% of control. The total oxyradical scavenging capacity measured in the digestive gland toward peroxyl, hydroxyl and peroxynitrite was also significantly reduced indicating a decreased resistance to oxidative stress generated by DPA (p<0.05, n=5). These results thus suggest the potential detrimental effects of DPA even at concentration as low as 50 microg/L on H. araneus.
DOI: 10.1016/j.marpolbul.2008.05.005
PubMed: 18599090
Affiliations:
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xml:lang="fr">France</country><wicri:regionArea>LEMA, EA 3222, Université du Havre, 25, rue Philippe Lebon, BP540, F-76058 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author><author><name sortKey="Forget Leray, Joelle" sort="Forget Leray, Joelle" uniqKey="Forget Leray J" first="Joëlle" last="Forget-Leray">Joëlle Forget-Leray</name></author><author><name sortKey="Bj Rnstad, Anne" sort="Bj Rnstad, Anne" uniqKey="Bj Rnstad A" first="Anne" last="Bj Rnstad">Anne Bj Rnstad</name></author><author><name sortKey="Camus, Lionel" sort="Camus, Lionel" uniqKey="Camus L" first="Lionel" last="Camus">Lionel Camus</name></author></analytic><series><title level="j">Marine pollution bulletin</title><idno type="ISSN">0025-326X</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholinesterase (metabolism)</term><term>Animals</term><term>Arctic Regions</term><term>Benzhydryl Compounds</term><term>Brachyura (drug effects)</term><term>Brachyura (enzymology)</term><term>Digestive System (drug effects)</term><term>Drug Resistance, Multiple</term><term>Gene Expression Regulation (drug effects)</term><term>Halogenated Diphenyl Ethers</term><term>Hydrocarbons, Brominated (pharmacology)</term><term>Hydrocarbons, Brominated (toxicity)</term><term>Muscles (drug effects)</term><term>Muscles (enzymology)</term><term>Phenols (pharmacology)</term><term>Phenols (toxicity)</term><term>Phenyl Ethers (pharmacology)</term><term>Phenyl Ethers (toxicity)</term><term>Phthalic Acids (toxicity)</term><term>Polybrominated Biphenyls</term><term>Reactive Oxygen Species (metabolism)</term><term>Water Pollutants (pharmacology)</term><term>Water Pollutants (toxicity)</term><term>Xenobiotics (pharmacology)</term><term>Xenobiotics (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acetylcholinesterase</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hydrocarbons, Brominated</term><term>Phenols</term><term>Phenyl Ethers</term><term>Water Pollutants</term><term>Xenobiotics</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Hydrocarbons, Brominated</term><term>Phenols</term><term>Phenyl Ethers</term><term>Phthalic Acids</term><term>Water Pollutants</term><term>Xenobiotics</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Arctic Regions</term><term>Benzhydryl Compounds</term><term>Halogenated Diphenyl Ethers</term><term>Polybrominated Biphenyls</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brachyura</term><term>Digestive System</term><term>Gene Expression Regulation</term><term>Muscles</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Brachyura</term><term>Muscles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Resistance, Multiple</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Arctic has become a sink for persistent organic pollutants (POPs) originating from lower latitudes, and relatively high levels have been found in different biota. Recent studies have identified detrimental effects on wildlife including endocrine disruption, impairment of enzyme activity, and reduced immune function. The Arctic spider crab, Hyas araneus, shown interesting potential for its use as sentinel organism in polar ecosystems. This study investigated the effect of 2,2',4,4'-tetra bromo diphenyl ether (BPDE), bisphenol A (BPA), and diallyl phthalte (DPA) on H. araneus in a three weeks exposure study. Expression of multixenibiotic resistance (MXR) proteins has been studied using the C219 monoclonal antibody which allows identifying an immunoreactive protein of 40 kDa in the digestive gland while no such protein could be observed in the gills. Expression of this protein was increased by exposure to DPA (+75%; p<0.05, n=10). All compounds significantly affected muscle acetylcholine esterase (AChE) activity (p<0.05, n=10) with 50 microg/L DPA having the strongest effect by lowering the value to 37% of control. The total oxyradical scavenging capacity measured in the digestive gland toward peroxyl, hydroxyl and peroxynitrite was also significantly reduced indicating a decreased resistance to oxidative stress generated by DPA (p<0.05, n=5). These results thus suggest the potential detrimental effects of DPA even at concentration as low as 50 microg/L on H. araneus.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li></settlement><orgName><li>Université du Havre</li></orgName></list><tree><noCountry><name sortKey="Bj Rnstad, Anne" sort="Bj Rnstad, Anne" uniqKey="Bj Rnstad A" first="Anne" last="Bj Rnstad">Anne Bj Rnstad</name><name sortKey="Camus, Lionel" sort="Camus, Lionel" uniqKey="Camus L" first="Lionel" last="Camus">Lionel Camus</name><name sortKey="Forget Leray, Joelle" sort="Forget Leray, Joelle" uniqKey="Forget Leray J" first="Joëlle" last="Forget-Leray">Joëlle Forget-Leray</name></noCountry><country name="France"><region name="Région Normandie"><name sortKey="Minier, Christophe" sort="Minier, Christophe" uniqKey="Minier C" first="Christophe" last="Minier">Christophe Minier</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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